Adrenaline production in stress is actually drug abuse.

How Ephedrine, Galantamine and Nicotine Treat Inflammation in Psoriasis

Adrenaline is involved in so many chronic diseases and most doctors have no clue about it. It is not actually the “stress” what destroys the body over time, it is the adrenaline and imbalanced adrenergic receptors what lead to health problems. Psoriasis is just one, but not the only one disease which involves the Autonomic Nervous System dysfunction including the dysfunctional vagus nerve.

Long-term stress is adrenaline abuse

If you experience a long-term emotional stress you are actually abusing the adrenaline because adrenaline is ultimately released always when we are stressed.

If the cells are constantly flooded with adrenaline they will desensitize themselves to its effects because that is the way how body reacts to every drug over time.

The problem with adrenaline desensitization is that adrenaline is endogenously produced (body produces own adrenaline) and therefore it is essential for proper function of the whole body (nervous system, hormonal system including the regulation of blood sugar levels).

So if the body desensitizes the cells to adrenaline there will be the whole host of new problems.

One is the effect on blood glucose levels which in turn will very possibly lead to hypoglycemia, hyperinsulinemia and weight gain. More gained fat leads to more inflammatory cytokines as you can read about it here “Psoriasis and overeating – binge eating is a dopaminergic problem”.

Hypoglycemia is one of the worst hidden conditions you can develop because it usually leads to more adrenaline production and makes the whole adrenaline problem even worse.

Another culprit about adrenaline desensitization is the specific desensitization of the neurons. Nervous system controls all the functions of body and having the nervous cells non-responsive to adrenaline may manifest as any symptom.

Brain fog, low motivation, fatigue, back pain, fibromyalgia, PTSD,… all these conditions are strongly linked to nervous system dysfunction.

Adrenaline, blood flow and psoriasis.The desensitization of cells to adrenaline may also severely impair the blood flow into the various organs and tissues as I have described in my previous post “Adrenaline: The effects of Alpha and Beta adrenergic receptors on vasoconstriction and blood flow in psoriasis”.

How to modulate the important adrenergic pathways?

The role of adrenergic receptors in inflammation was repeatedly confirmed. It is also proved that beta 2 adrenergic receptor agonists (activators) possess the anti-inflammatory effects.[11,12]

There are 2 major ways how you can directly affect the adrenergic pathways taking just the natural products:

1. Improving the response of alpha-7-nicotinic acetylcholine receptor

Galantamine increases the acetylcholine levels and sensitizes the alpha-7-nicotinic acetylcholine receptors. Nicotine binds to and activates the nicotinic acetylcholine receptors including the alpha-7-nicotinic acetylcholine receptor.

2. Activation of Beta 2 adrenergic receptor

Ephedra contains an ephedrine which is a strong agonist (activator) of the adrenergic receptors (including the beta 2 adrenergic receptor).

Which way to go?: Galantamine vs. Ephedra vs. Nicotine

  • Galantamine – the most recommended way, generally safe and well researched thus suitable for long-term use
  • Ephedra – less recommended way, generally not intended for long-term use in healthy people
  • Nicotine – not recommended, possibility of developing the addiction, nicotine may be an option only if you know 100% what are you doing (so not intended for most people)

Inflammatory reflex – adrenaline and acetylcholine

Look at the next picture for the better understanding why ephedrine (from Ephedra), galantamine (from snowdrop or spider lily) and nicotine (from tobacco) as 3 different natural molecules may significantly help with psoriasis and I believe that not just with psoriasis.

Inflammatory reflex - psoriasis, adrenaline, ephedrine, nicotine and galantamine

Inflammatory reflex. If everything goes well the inflammation is balanced through activation of beta 2 adrenergic receptor on the T-cells which release the acetylcholine. If that acetylcholine binds to alpha-7-nicotinic acetylcholine receptor on the macrophages (type of immune cells heavily involved in inflammation) the production of TNF-alpha and other inflammatory cytokines is strongly inhibited.
Image source: Ulf Andersson and Kevin J. Tracey. Neural reflexes in inflammation and immunity. Published June 4, 2012 JEM vol. 209 no. 6 1057-1068 The Rockefeller University Press

Endotoxin-activated macrophages are heavily responsible for TNF-alpha, IL-1 Beta and IL-6 production in psoriasis and many other chronic health problems.[1]

What you can learn from the picture above is that there are two ways how to suppress the excessive inflammation:

  • by stimulation of beta 2 adrenergic receptors on T-cells
    or
  • by activation of alpha-7-nicotinic acetylcholine receptors on macrophages.

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2 Responses

  1. ghul says:

    hey quick question.
    wouldnt the body adapt to chronic exposure of Galantamine and at the end be worse of then before?

    • John says:

      I don’t think so because Galantamine is not an agonist of Nicotinic Acetylcholine receptors (like Nicotine).

      Galantamine just improves the response of existing Acetylcholine in the system which binds to the acetylcholine receptors.

      So when Galantamine supplementation stops then this improved response stops too but the basic response stays in my opinion.

      Sure, Galantamine possesses the Acetylcholinesterase inhibitory properties but that should not cause worsening of psoriasis after discontinuation of supplementation in my opinion.

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