Colostrum: The Anti-Inflammatory and Anti-Microbial Effects For Psoriasis


When mentioning colostrum most people think probably just about its immunoglobulin content and perhaps are afraid that it may not be the best supplement for psoriatics because psoriasis is considered to be an autoimmune condition and immune support would cause just more inflammation.

The reasons why psoriasis can not be an autoimmune disease are stated in many of my blog posts so I won’t address this topic now.

In this post I would like to focus more on anti-endotoxin effects of colostrum since endotoxins as you may know are very inflammatory molecules (parts of cell wall of gram-negative bacteria) which start the inflammatory cascade.

Colostrum consists of many different bioactive molecules – lactoferrin, lysozyme, proline rich peptides and others.

Colostrum vs Lactoferrin or both?

The study published in 2002 – “Endotoxin inactivation by enterally applied colostrum of different composition” – concluded that “gammaglobulin-enriched and especially lactoferrin-enriched colostrum decreased endotoxin values by more than 50%. The most effective endotoxin elimination was seen with lactoferrin alone.”

The study was performed on rats using the administered endotoxin of E. coli and orally applied enriched colostrum and lactoferrin.


From this results it can be concluded that not only gammaglobulin but especially lactoferrin seems to be responsible for the elimination of endotoxin with regard to enterally applied colostrum preparations.
“[1]

From the results of this study it seems like the standalone lactoferrin supplement would be more effective for attenuating the inflammation in psoriasis.

In similar study one of the authors with his colleague got even better results when combination of colostrum with lactoferrin brought about 80% reduction in plasma endotoxin activity.

In both studies the albumin was used instead of colostrum in control groups.

There was also a significant reduction in bacterial contamination of lymph nodes and peritoneal lavages (fluids in the abdomen) when colostrum was administered to animals with endotoxemia.

Image Source: Döhler JR, Nebermann L. Bovine colostrum in oral treatment of enterogenic endotoxaemia in rats. Crit Care. 2002 Dec;6(6):536-9.

 

Image Source: Döhler JR, Nebermann L. Bovine colostrum in oral treatment of enterogenic endotoxaemia in rats. Crit Care. 2002 Dec;6(6):536-9.

 

Image Source: Döhler JR, Nebermann L. Bovine colostrum in oral treatment of enterogenic endotoxaemia in rats. Crit Care. 2002 Dec;6(6):536-9.

The scientists think “that not only gammaglobulin but especially lactoferrin seems to be responsible for the elimination of endotoxin with regard to enterally applied colostrum preparations.”[4]

There are some testimonials from people with psoriasis or acne besides many other conditions who claim to greatly improve or totally cleared up their skin with Lactoferrin supplement.

Anti-endotoxin antibodies in Colostrum

Yes, there are the molecules in colostrum which act as the anti-endotoxin antibodies.

There is also a patent application describing the composition of colostrum enriched with anti-endotoxin antibodies.


The present invention provides a colostrum formulation enriched in anti-endotoxin antibodies. Further provided is a method for reducing endotoxemia and blocking the onset of sepsis in patients comprising administering to the patients a colostrum formulation enriched with anti-endotoxin antibodies. Further provided is a method for treating an individual for hemolytic uremic syndrome or of protecting an individual against hemolytic uremic syndrome, comprising the step of administering to the patient an effective amount of the composition of the present invention.

Source: http://www.google.com/patents/WO2014121045A1?cl=en

Human breast milk contains the anti-endotoxin antibodies


The particularly high levels of antiendotoxin antibodies in cases of neonatal infection may present a special maternal protection for premature infants.
” [3]

The study published 20 years ago proved

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4 Responses

  1. Charles says:

    Slightly confused by some of the links in the article. Are you recommending the lactoferrin alone or the colostrum supplement as the better approach?

    • John says:

      What links do you mean?

      The product links or the links to studies?

      Generally, there is about 5 mg of Lactoferrin per 1 gram of colostrum.

      So, to get the 250 mg of Lactoferrin – which is a standard per capsule if you buy a dedicated supplement – you would need to take 50 grams of colostrum.

      Some people do that but economically it is too expensive for many.

      That’s why I would say that Lactoferrin is better if you asked if it would be better to take 1 gram of colostrum daily or 1 capsule of Lactoferrin.

      But keep in mind that Colostrum contains the other bioactive molecules which can not be replaced with Lactoferrin only.

      This article is about the colostrum and lactoferrin effects on endotoxins, so the other bioactive molecules like Immunoglobulins are not discussed here in details.

      But I still think that it would be more effective to take more than just about 1 gram of colostrum daily.

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