Colostrum: The Anti-Inflammatory and Anti-Microbial Effects For Psoriasis

When mentioning colostrum most people think probably just about its immunoglobulin content and perhaps are afraid that it may not be the best supplement for psoriatics because psoriasis is considered to be an autoimmune condition and immune support would cause just more inflammation.

The reasons why psoriasis can not be an autoimmune disease are stated in many of my blog posts so I won’t address this topic now.

In this post I would like to focus more on anti-endotoxin effects of colostrum since endotoxins as you may know are very inflammatory molecules (parts of cell wall of gram-negative bacteria) which start the inflammatory cascade.

Colostrum consists of many different bioactive molecules – lactoferrin, lysozyme, proline rich peptides and others.

Colostrum vs Lactoferrin or both?

The study published in 2002 – “Endotoxin inactivation by enterally applied colostrum of different composition” – concluded that “gammaglobulin-enriched and especially lactoferrin-enriched colostrum decreased endotoxin values by more than 50%. The most effective endotoxin elimination was seen with lactoferrin alone.”

The study was performed on rats using the administered endotoxin of E. coli and orally applied enriched colostrum and lactoferrin.


From this results it can be concluded that not only gammaglobulin but especially lactoferrin seems to be responsible for the elimination of endotoxin with regard to enterally applied colostrum preparations.
“[1]

From the results of this study it seems like the standalone lactoferrin supplement would be more effective for attenuating the inflammation in psoriasis.

In similar study one of the authors with his colleague got even better results when combination of colostrum with lactoferrin brought about 80% reduction in plasma endotoxin activity.

In both studies the albumin was used instead of colostrum in control groups.

There was also a significant reduction in bacterial contamination of lymph nodes and peritoneal lavages (fluids in the abdomen) when colostrum was administered to animals with endotoxemia.

Image Source: Döhler JR, Nebermann L. Bovine colostrum in oral treatment of enterogenic endotoxaemia in rats. Crit Care. 2002 Dec;6(6):536-9.

 

Image Source: Döhler JR, Nebermann L. Bovine colostrum in oral treatment of enterogenic endotoxaemia in rats. Crit Care. 2002 Dec;6(6):536-9.

 

Image Source: Döhler JR, Nebermann L. Bovine colostrum in oral treatment of enterogenic endotoxaemia in rats. Crit Care. 2002 Dec;6(6):536-9.

The scientists

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4 Responses

  1. Charles says:

    Slightly confused by some of the links in the article. Are you recommending the lactoferrin alone or the colostrum supplement as the better approach?

    • John says:

      What links do you mean?

      The product links or the links to studies?

      Generally, there is about 5 mg of Lactoferrin per 1 gram of colostrum.

      So, to get the 250 mg of Lactoferrin – which is a standard per capsule if you buy a dedicated supplement – you would need to take 50 grams of colostrum.

      Some people do that but economically it is too expensive for many.

      That’s why I would say that Lactoferrin is better if you asked if it would be better to take 1 gram of colostrum daily or 1 capsule of Lactoferrin.

      But keep in mind that Colostrum contains the other bioactive molecules which can not be replaced with Lactoferrin only.

      This article is about the colostrum and lactoferrin effects on endotoxins, so the other bioactive molecules like Immunoglobulins are not discussed here in details.

      But I still think that it would be more effective to take more than just about 1 gram of colostrum daily.

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