Psoriasis: The Gut-Brain Axis

We all know that stress can significantly impair the blood flow throughout the body. I published the blog posts and mostly video about this issue and how it relates to psoriasis before.

 

Adrenaline as a fight-or-flight hormone redirects the blood flow from digestive organs into the brain and muscles in order to do the best to resolve the acute threat.

However, living in stress on a daily basis means that you won’t absorb nutrients from food and low output of pancreatic and intestinal enzymes leave a lot of food (starches and disaccharides) for bacterial and fungal fermentation. Pancreatic (mal)function was suspected to be involved in psoriasis pathogenesis in the past. Today, everybody should know already that psoriasis has many underlying causes (nutritional deficiency, dental infection, yeast infection,…) and it is only the final processes of pathogenesis which are common in everybody (ANS dysfunction, microorganisms induced inflammation of the skin,…)

What is Mesenteric blood flow?

A blood flow into the gut (small intestine, colon, pancreas) in medical books is called a mesenteric blood flow.

 

Low blood flow = low oxygenation of the tissues = low ATP (energy production) = decreased production of the digestive enzymes and other molecules = SIBO and Candida infections = inflammation.

 

OK, now those of you who like to oppose everything will argue that there is a lot of other causes of SIBO and Candida infections of the gut.

Well, after you finish this blog post you should know why mesenteric blood flow is heavily involved in digestion, SIBO, Candida and overall health.

Image Source: J. H. Meurman J. H. Meurman E. Siikala M. Richardson M. Richardson R. Rautemaa R. Rautemaa. Non-Candida albicans Candida yeasts of the oral cavity. Jan 2007. Downloaded from ResearchGate.net

 

But one of the most important things you should realize is that if you have not enough oxygen in the cells of digestive organs you can eat anything and you will still struggle digesting that food. If you had your small intestine or pancreas working just about 10% of their relative normal healthy performance then you would loose weight, had SIBO, Candida and other problems because the undigested food would ferment in your gut.

The Brain-Gut Axis and chronic inflammation

The scientific paper from 2011 – “Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options” – mentions the following six effects of stress on gut physiology:


1) alterations in gastrointestinal motility;
2) increase in visceral perception;
3) changes in gastrointestinal secretion;
4) increase in intestinal permeability;
5) negative effects on regenerative capacity of gastrointestinal mucosa and mucosal blood flow;
6) negative effects on intestinal microbiota;
” [8]

 


Exposure to stress results in alterations of the brain-gut interactions (“brain-gut axis”) ultimately leading to the development of a broad array of gastrointestinal disorders including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and other functional gastrointestinal diseases, food antigen-related adverse responses, peptic ulcer and gastroesophageal reflux disease (GERD).
” [8]

Endotoxins decrease the blood flow in the gut

When you live in stress and your body is switched in fight-or-flight instead of rest-DIGEST-repair you slowly progressing into a state when bacteria and yeast overgrow in your intestines.

More bacteria and yeast means more endotoxins and toxins which place a burden on liver, nervous and immune system.

 

The scientists proved that LPS (endotoxins) decrease the mesenteric blood flow (blood flow in the gut). And even though it was previously reported that adrenaline tolerance decrease the mortality in endotoxic shock this study from 1999 proved that adrenaline tolerance does not prevent decrease

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