Taurine Decreases Inflammation In Psoriasis
When you start learning about the effects of taurine you can find really anything. From its positive effects on nervous system, liver (bile production and bile flow) and heart to its anti-inflammatory effects and possibly anti-psoriatic effects I am going to present here right now.
Psoriasis as you probably know from this blog is caused by Autonomic Nervous System dysfunction which in turn is (usually if not always) caused by systemic inflammation.
This inflammation is caused mostly by endotoxins (LPS) – the molecules from gram-negative bacteria – which if not removed by liver induce the inflammatory cascade resulting in production of TNF-alpha, NFkappaB, prostaglandins, interleukins and histamine.
Inflammation is good if it is fully controlled by our bodies, however, once it gets out of control for any reason we may need to decrease it with supplements, diet and herbs in order to get out of the vicious circle.
Taurine is one of those supplements which may greatly help us with that task. A big advantage of this supplement is that it is relatively cheap compared to most others solutions and it is very effective.
The other two of 3 most common reasons of inflammation besides the endotoxins or infection are deficiency and toxicity – but this is not the topic of this blog post.
– Taurine and its effects on endotoxins
– Taurine and its effects on inflammation
– What dosage is effective for inflammation?
– How much taurine should I take a day?
– Why is taurine in energy drinks?
Even though I have mentioned the term “reperfusion injury” before on this blog I will give you an explanation of what it is here because you will meet with this term further below in this post.
What is reperfusion injury?
Reperfusion injury or reperfusion insult, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia). The absence of oxygen and nutrients from blood during the ischemic period creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than (or along with) restoration of normal function.
Source: Wikipedia.com – https://en.wikipedia.org/wiki/Reperfusion_injury
Taurine and liver
In one in vitro rat study the researchers measured the effects of taurine on endotoxin (LPS) stimulated TNF-alpha production.
Activation of Kupffer cells by lipopolysaccharide (LPS) plays a pivotal role in the onset of pathophysiological events that occur during endotoxemia and intracellular calcium ([Ca2+]i) is involved in LPS-stimulated cytokine production. Recently, it was shown that Kupffer cells contain a glycine-gated chloride channel. Because taurine, a ubiquitous sulfur-containing beta-amino acid, acts similarly to glycine in neurons by causing hyperpolarization, it was hypothesized that taurine would act via a similar mechanism, blunting the LPS-induced increase in [Ca2+]i in Kupffer cells.
These results indicate that taurine activates a glycine-gated chloride channel in Kupffer cells causing chloride influx. In addition, LPS-induced TNF-alpha production was reduced by more than 40% by taurine, an effect that was also reversed by strychnine. In conclusion, taurine blocks the increase in [Ca2+]i due to LPS and significantly reduces TNF-alpha production by mechanisms involving chloride influx into the Kupffer cell.
What can I say new here?
Endotoxins are the cause of so many health problems that it is unbelievable…
It is suspected if not confirmed that endotoxins play a major role in alcohol-induced liver disease. In other words it is not the alcohol what makes your liver suffer rather than endotoxins which are absorbed into the blood and go to the liver after you drink the alcohol.