My Psoriasis Cause Theories
Endothelin may be one of the causes of redness and scaling in psoriasis since it may cause local hypoxia in the skin.
The most powerful known vasoconstrictor which is produced by the body is endothelin.  There are the studies which prove that the blood from psoriasis plaques contains the significantly higher levels of endothelin than the blood from psoriatics’ normal skin and skin from healthy people.[18, 19]
However it may be also that the first the psoriasis plaque is hypoxic (thick blood – platelets, rouleaux, fibrin, etc.) and the body in response to hypoxia release the endothelin.
|Psoriasis (guttate) on arm – the skin around the circles looks pale – like there was low blood flow. These circles are called – Woronoff rings.|
That’s why I am not convicted that psoriasis is the autoimmune disorder. I think that the skin cells which are destroyed by our immune system are already damaged by the bacteria/toxins and low oxygen content (the cells are dying from oxygen and nutrient starvation due poor blood flow) and