My Psoriasis Cause Theories
Endothelin may be one of the causes of redness and scaling in psoriasis since it may cause local hypoxia in the skin.
The most powerful known vasoconstrictor which is produced by the body is endothelin.  There are the studies which prove that the blood from psoriasis plaques contains the significantly higher levels of endothelin than the blood from psoriatics’ normal skin and skin from healthy people.[18, 19]
However it may be also that the first the psoriasis plaque is hypoxic (thick blood – platelets, rouleaux, fibrin, etc.) and the body in response to hypoxia release the endothelin.
|Psoriasis (guttate) on arm – the skin around the circles looks pale – like there was low blood flow. These circles are called – Woronoff rings.|
That’s why I am not convicted that psoriasis is the autoimmune disorder. I think that the skin cells which are destroyed by our immune system are already damaged by the bacteria/toxins and low oxygen content (the cells are dying from oxygen and nutrient starvation due poor blood flow) and that’s why our bodies make the new skin cells.
Redness is just a symptom of inflammation because the pathogens and toxins are there and body tries to clean up that tissues.
Endothelin is also found in the tumors so it fits with the theory that the cancers are also often caused by virus. Endothelin is involved also in other autoimmune considered diseases, but the question is if it is the cause (endothelin release caused by virus/bacteria) or the defense mechanism of the body.
I have two theories about the cause of psoriasis:
There are known viruses that cause the cells in the body to release endothelin – a powerful vasoconstrictor. In my first theory the virus/mycoplasma/CWD bacteria cause the vessels in the skin to constrict (maybe in order to create the low oxygen environment – oxygen deprived skin; or to avoid the immune cells). As the infection in the skin spreads the plaque gets bigger and bigger.
|Small plaque – infection in the microvessel(s)|
|Infection spreads – plaque grows|
|The infection/blocked vessel in deeper part of the skin|
You should imagine the smallest vessels in these picture as very tiny tubes which are just about 5-10 micrometers wide (red blood cells are about 8 micrometers wide) so just one red blood cell can flow through it at a time. And even the one RBC have to change the shape to get through the smallest micro-vessels (capillaries).
The cause why the plaques are red is probably not just because of the infection there (which causes the immune reaction) but also because of the inflammation/oxidative stress from low blood supply which should deliver enough oxygen, nutrients and remove the metabolic wastes from the cell metabolism.
The reason why there is a lot of dry skin is probably just because the body have to constantly produce new cells since the old ones are not even fully/right developed due to lack of oxygen and nutrients and are also damaged by metabolic wastes (oxidative stress).
2nd theory – I believe in this theory more
In the upper part of the skin is the pathogen which body tries to destroy. Since it is the intracellular pathogen (in the psoriasis plaque there are the recruited neutrophils and the neutrophils are often a sign of intracellular infection)  body makes the skin cells to proliferate fast so the pathogens in them will die along with the dead cells in which they hide. It is very possible that the infection is the intracellular Streptococcus pyogenes since the onset of guttate psoriasis is often 2-3 weeks after the Streptococcal pharyngitis (strep throat) caused by Streptococcus pyogenes.[196, 197, 198]
In order to slow the pathogen from spreading the body constrict the blood vessels in a way that the blood can easily flow just in a way from the body into the skin and not in a reverse way so the pathogens wouldn’t spread easily by flowing through the blood to another location in the body. Otherwise we would have psoriasis everywhere and had covered 100% of the skin on