Ciclosporine – A Cholesterol Raising Fungal Toxin
People who decide to take ciclosporin knows just a little about it and its effects. Doctors are used to prescribe this drug as “effective” psoriasis treatment despite its serious “side effects”.
Ciclosporin is actually a fungal toxin produced by fungus Tolypocladium inflatum which may naturally occur in soil. Its main effect on the body is suppression of the immune system functions.
Psoriasis and ciclosporine
So the doctors consider suppressing already suppressed immune system as a way to go. They don’t think about one profound effect which comes after going off the ciclosporin – psoriasis usually comes back with a vengeance. One possible and very probable reason is that immunosuppression due to ciclosporin allowed the infection causing microbes in the body spread and proliferate.
Cislosporine may be useful in cases of organ transplantation but use it as a long-term treatment for psoriasis or rheumatoid arthritis? No way.
Everything would be OK if the only effect was clearing the psoriasis; however frequent and serious infections, kidney toxicity, neurotoxicity, elevated cholesterol levels, liver damage and cancer are just a few “side effects” of this drug.
Mechanism of action
Ciclosporin works by inhibiting the functions of the immune cells – lymphocytes (especially T-cells) – which are responsible for important immune reactions in the body.
Now you may think that psoriasis is actually an overactive immune system problem considering that immunosuppressive treatment works. It is not!
One of the effects of ciclosporin is reduction of TNF-alpha production which is heavily involved in inflammation and inflammation in turn affects the blood coagulation process.
However, it is not just about the TNF-alpha and there are also many other inflammatory messengers blocked when their producers – the immune cells – are poisoned by ciclosporin. The biochemical pathways are very complex but in the end ciclosporin makes the body less inflamed and blood thinner which is good but what is the price paid.
The doctors must prescribe the dosage high enough for the ciclosporin to have any effect on psoriasis. However, due to its toxicity many patients still have psoriasis despite taking this drug. If the doctors prescribed even the higher dose just to completely clear up the skin of the patients they would develop the serious infections and die before the psoriasis cleared up.
Interesting “side effects” of ciclosporin
One very interesting fact about ciclosporin is that it raises cholesterol levels in the body.
How many people who don’t take any drugs have high cholesterol levels? Millions of people.
What causes it? No one knows…
But if ciclosporin which is a fungal toxin raises the cholesterol levels could it be possible that the other people are infected with some fungus which produces the toxin with similar effects to ciclosporin right in their bodies?
I think, yes.
Statins as antifungals
And here comes another great discovery…
The science proves that statin drugs are effective antifungals.
Do we need more facts to make the decision what may contributing to or causing this epidemic of hypercholesterolemia?
Is it possible that statin drugs lower the cholesterol levels at least partially by killing the fungi in the body?
Some studies concluded that it is impossible to reach the effective levels of statins to be an effective antifungals in the body. The problem is again their toxicity which would damage the body too much.
However some researchers recommend statins as a part of antifungal therapy combined with commonly used antifungal drugs.
I am not recommending statins as antifungal agents or for lowering the cholesterol levels since they have also serious “side effects” like muscle atrophy (wasting syndrome).
So statins prescribed to lower cholesterol levels are also relatively potent antifungals. Or should we say that antifungal-statins kill fungi despite being promoted as the drugs to lower cholesterol levels?
1) Nyilasi I, Kocsubé S, Krizsán K, Galgóczy L, Papp T, Pesti M, Nagy K, Vágvölgyi