Bromelain: The Anti-Inflammatory and Clots Dissolving Effects for Psoriasis
Considering that inflammation is at the root of most chronic diseases we can just praise the effects of natural and strong proteolytic enzymes like bromelain.
You can feel the effects of bromelain in about 20-30 minutes after the ingestion on an empty stomach. If you had stiff spine or other joints due to chronic inflammation and thick blood in the body you would experience possibly very profound alleviation of the symptoms in just about 30 minutes.
The only sad part of bromelain is that these strong (muscle relaxing) effects are usually present for only about 1 or 2 hours after the ingestion of supplement. A lot of depends on the dosage and the way of intake.
It is convenient to open the bromelain capsule and put it in with a little bit of water in the shaker (like those the bodybuilders use). This way the bromelain has a better chance to be absorbed into the bloodstream at a higher rate and ratio than when taken in capsules.
Science on bromelain
Bromelain belongs to a group of proteins called proteases. There are some differences in bromelain obtained from fruit and from pineapple stem but both have the strong proteolytic effects. The bromelain you can buy as the supplement is usually extracted from the stems of the pineapple.
“Bromelain is a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors.
Bromelain is considerably absorbable in the body without losing its proteolytic activity and without producing any major side effects. Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics. It also relieves osteoarthritis, diarrhea, and various cardiovascular disorders. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.”
Acceleration of wound healing is another great effect of bromelain.
The animal studies showed that bromelain is absorbed at about 40% from the intestine. Its effects proved to be mostly anti-edema, anti-inflammatory and anticoagulant. Fibrinolysis (blood clots dissolving), fibrin synthesis inhibition, fibrin, fibrinogen degradation inhibitory and inflammatory mediators degrading properties are mostly responsible for bromelain’s positive effects.
Bromelain also proved to lower the kininogen (precursor to chemicals involved in inflammation and coagulation) and bradykinin (inflammation mediating vasodilator) levels in serum and the tissues. This pineapple enzyme reduces also the prostaglandin synthesis which leads to inflammation. There are even the studies which proved bromelain to be able to inhibit the tumours. Its effects seem to be dose-dependent.
The study performed on healthy men proved bromelain to be absorbed into the blood and the half-life of bromelain was estimated to be 6-9 hours. When 3 grams/day were administered the plasma levels reached 5,000 pg/ml by 48 hours. Absorbed bromelain was found to be associated with alpha 2-macroglobulin and alpha 1-antichymotrypsin levels – the two plasma proteins which degrade the protein breaking enzymes (proteases) like bromelain.
Plasmin is one of those proteases; it is produced in the body to help in fibrinolysis.
Bromelain breaks down the TNF-alpha
Bromelain inhibits the lipopolysaccharide (endotoxin) induced cytokine production as well as directly degrades the TNF-alpha and IL-1 beta molecules. Both the TNF-alpha as well as IL-1 beta are inflammatory mediators involved in many chronic diseases including the psoriasis. Bromelain also dose dependently inhibits endotoxin-induced prostaglandin E2, thromboxane B2 and COX-2 mRNA expression.[7,8]
The study in 2004 proved that alpha 2-macroglobulin which is a strong anti-fibrinolytic protein expresses significantly stronger effects in critically ill and septic patients.
The researchers studied its protease inhibitory effects against the bromelain in the plasma of critically ill or septic patients whose health conditions are accompanied by massive production of inflammatory mediators.