Chromium

Chromium May Be Effectively Used for Psoriasis

Insulin resistance, elevated fasting blood sugar, hypoglycemia – all these symptoms are common in chronic inflammatory conditions like psoriasis.

Natural products like cinnamon, omega 3 fatty acids or chromium supplements may effectively lower fasting blood sugar levels via their positive effects on insulin sensitivity.

Decreased insulin sensitivity leads to higher insulin production which in turns makes a whole lot of other problems. There is a report describing the negative effects of insulin on psoriasis in diabetic patient who switched from metformin to insulin.[1]

Having too much insulin flowing in the blood is not good.

Transporting the glucose into the cells is just one effect of insulin. Having too much insulin in the blood will increase the glucose uptake but dysregulate the other pathways  which are affected by the insulin.

Two of those processes are DNA replication and triglyceride synthesis.

Chromium improves insulin sensitivity

People with psoriasis exhibit reduced insulin sensitivity compared to healthy people without psoriasis.[2]

Blood glucoseThe study performed in group of 39 elderly diabetics (average age 73 years) researched the effects of chromium supplementation on fasting blood glucose. Supplementation with 200mcg of chromium picolinate twice a day for 3 weeks improved blood glucose levels significantly – 190 mg/dL vs 150 md/dL – compared to the baseline values. Chromium supplementation helped also to reduce the total cholesterol levels (from 235 mg/dL to 213 md/dL) and triglycerides.[3]

Even 100mcg of chromium yeast is enough to make a significant difference on insulin sensitivity in type 2 diabetics.[4]

Improved insulin sensitivity results in less insulin production which means also less hypoglycemic episodes and subsequent adrenaline release. I have a long post about hypoglycemia here – “Hypoglycemia causes night sweating, peeing, insomnia and anxiety”.

Reactive hypoglycemia graph

A huge problem of hyperglycemia (high blood sugar levels) is that high blood sugar levels negatively affect the innate immune system and increase the inflammation in the body.[6]

Cleaning up the small intestine of endotoxins is the key because inflammation (caused by endotoxins) leads to insulin resistance. One possible mechanism of inflammation induced insulin resistance is by TNF-alpha stimulation of p55 TNF receptor what subsequently affects the insulin regulated pathways in the cells.[5]

Insulin as the symptom

Insulin resistance and thus increase in insulin production is not a problem rather than a symptom.

It is usually a symptom of inflammation caused by endotoxins from small intestine or dental infection (root canal teeth). A lot of people cured their diabetes just by removing the infected teeth from their bodies. In just 2 or 3 days after the procedure the levels of blood sugar significantly improved and often stabilized on healthy levels.

The scientists have identified the bacterial lipopolysaccharide (LPS) also called an endotoxin as the triggering inflammatory factor of the onset of insulin resistance, obesity and diabetes.[7]

So supplementation with chromium shouldn’t be a destination rather than a tool how to improve the glycemic control while managing the endotoxin overload.

Bile flow is essential for breaking down the endotoxins in small intestine so they won’t get absorbed into the bloodstream.

 

References:

1) Allan F. Moore, MD, Tiffany Soper, RN, Natalie Jones, PA, Joop Grevelink, MD and Nicolas Abourizk, MD. Psoriatic Exacerbation Associated With Insulin Therapy. Diabetes Care May 2008 vol. 31 no. 5 e31.
2) Gyldenløve M, Storgaard H, Holst JJ, Vilsbøll T, Knop FK, Skov L. Patients with psoriasis are insulin resistant. J Am Acad Dermatol. 2015 Apr;72(4):599-605.
3) Rabinovitz H, Friedensohn A, Leibovitz A, Gabay G, Rocas C, Habot B. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res. 2004 May;74(3):178-82.
4) Racek J, Sindberg CD, Moesgaard S, Mainz J, Fabry J, Müller L, Rácová K. Effect of chromium-enriched yeast on fasting plasma glucose, glycated haemoglobin and serum lipid levels in patients with type 2 diabetes mellitus treated with insulin. Biol Trace Elem Res. 2013 Oct;155(1):1-4.
5) Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem. 1996 May 31;271(22):13018-22.
6) Collier B1, Dossett LA, May AK, Diaz JJ. Glucose control and the inflammatory response. Nutr Clin Pract. 2008 Feb;23(1):3-15.
7) Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007 Jul;56(7):1761-72.



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