Potentially Unsafe Legal Stimulants, Anti-Depressants and Anti-Anxiety Supplements

A lot of people with chronic diseases including psoriasis are trying to find some magic supplement or drug which could at least improve their health. Some of them may become easily acutely unsafe and the others may cause long-term negative side effects which are not necessarily life-threatening.

The next list is compiled according to my experiences what people are the most interested in.

Keep in mind that EVERY substance in the world including the water has its lethal dose. Therefore the next list does not include death as one of the negative side effects of any substance mentioned below.

This post is not intended as recommendation for use of any herb, supplement or substance mentioned below!

Very Common Drugs

The two most commonly used stimulants are caffeine and nicotine.

Neither one of these drugs is proved to be significantly physically addictive but profound psychological addiction is surely present at least with nicotine.


Caffeine in low doses like one cup of coffee is generally safe but increases the effects of many other stimulants and drugs. Therefore it is advised not to combine it with anything else!

Positive: wakefulness, stimulation, motivation
Negative: insomnia, anxiety, raised blood pressure, heart problems (heart attack)
Onset of Effects: 30 – 45 minutes
Duration of Effects: appx. 3- 6 hours


Transdermal patches or vaping are preferred ways how to administer the nicotine in those who need it for some reason.

There is no need to start using the nicotine if one has no problem already.

Nicotine may help with

anxiety, depression, POTS and inflammation generally.

Neutral: appetite suppression
Positive: anti-anxiety effects, stimulation, anti-depressive effects
Negative: anxiety, panic attacks, nausea
Onset of Effects: 10 seconds (by inhalation – vaping or smoking)
Duration of Effects: appx. 1 – 2 hours

Adaptogens and Mood Improving Supplements

Adaptogens like Mucuna Pruriens and Rhodiola Rosea affect the dopaminergic system so their effects may persist in some way for a long time after the discontinuation of the supplementation.

Those supplements are not recommended for those who experience psychosis, impulsive behavior or those who are prone to addictions including the gambling.

Mucuna Pruriens

The major active ingredient in Mucuna Pruriens is amino acid L-DOPA. People report less negative effects when taking Mucuna Pruriens instead of pure L-DOPA powder.

Neutral: libido improvement
Positive: motivation, anti-anxiety effects
Negative: hypersexuality, impulsive behavior (gambling), addictive behavior
Onset of Effects: 1 hour (oral intake)
Duration of Effects: appx. 2 – 5 hours

Rhodiola Rosea

Rhodiola is one of the best anti-anxiety and anti-depressive herbs out there. The effects may be very strong so do not combine it with ANY other substance – neither coffee!

Neutral: libido improvement
Positive: huge increase in motivation, anti-depressive and anti-anxiety effects
Negative: hypersexuality, Cowper’s gland leakage, psychosis, irritability, impulsive behavior
Onset of Effects: 1 – 5 hours (gradual onset)
Duration of Effects: appx. 12 – 24 hours (even more when administered repeatedly)


Sulbutiamine is a synthetic form of vitamin B1 which crosses the blood-brain-barrier more easily than other forms of vitamin B1.

Positive: stimulation, improved memory and concentration
Negative: insomnia, headache
Onset of Effects: 30 – 90 minutes
Duration of Effects: 4 – 8 hours



Even though the possession and sale of pure ephedrine is illegal in many countries it may be possible to get the ephedrine containing herb called Ephedra which is native to China.

Ephedra - psoriasis and adrenergic receptors.

Neutral: weight loss, appetite suppressant
Positive: mild stimulation and euphoria, relieve nasal congestion
Negative: heart problems (high blood pressure, irregular heartbeat,

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