Adrenal Fatigue Is Bacterial Infection
This post will be just a short overview why you should stop hunting the useless supplements and protocols for adrenal “fatigue”:
Don’t get me wrong some of those supplements are very helpful when used right but rarely completely resolve the underlying problem. They may work for some time and after that people usually just up the dosages in hope they need to take “more of this and more of that” to get better.
You should understand that adrenal “fatigue” is caused by toxicity and deficiency just like every other chronic disease! In other words: adrenal fatigue is caused by bacterial infection.
Adrenal “fatigue” caused by endotoxin induced inflammation
The scientific paper “Characterization of the LPS-induced inflammation of the adrenal gland in mice.” describes the aspects of endotoxemia and associated adrenal gland insufficiency.
The authors concluded that adrenal dysfunction which is so often present in critically ill patients including the patients with sepsis may be the result of LPS induced inflammation.
In mice the systemic administration of endotoxin induced systemic inflammatory response syndrome (SIRS). Administration of endotoxin (LPS) led to increased levels of many proinflammatory cytokines, chemokines and other molecules. This caused massive infiltration of immune cells into the adrenal gland.
This endotoxin mediated inflammation was associated with increased cell death of adrenocortical and chromaffin cells.
Endotoxins disrupt the proper HPA axis function
It is well known that endotoxins are a powerful systemic stressor which activates the HPA axis. The major HPA axis response induced by endotoxin challenge is mediated via these cytokines: IL-1, IL-6 and TNF-alpha. These cytokines are the same which are heavily involved in inflammation associated with psoriasis. These cytokines stimulate the immune cells which in turn stimulate the various HPA axis pathways.
So even if you ever believed in adrenal “fatigue” as real organ fatigue this endotoxin induced HPA axis activation would perfectly fit in your belief model.
Scientific data from rat study proved that previous exposure to endotoxins results in hyporesponsiveness of adrenal glands to ACTH stimulation. ACTH is a major hormone responsible for activation of cortisol release.
Pretreatment with lipopolysaccharides (LPS – endotoxin) caused a significant decrease in corticosterone production which is a major glucocorticoid in rats.
Now just look at the next picture. You can see that ACTH levels in psoriatics are significantly higher and cortisol significantly lower than in healthy people. The results are the same in people with psoriasis as they are in the rats exposed to endotoxins.
Endotoxins are considered as the cause of psoriasis also by L. Bertók who published many papers about the importance of bile acids for breaking down the endotoxins in the small intestine.
All this data give us a clue that all those saliva cortisol tests and cortisol replacement therapies used for adrenal “fatigue” are mostly useless.
If endotoxemia which means bacterial infection causes low cortisol and overall adrenal insufficiency then why would anybody take replacement therapies instead of eliminating the infection?
Short-term replacement therapy may be OK and speed up the healing but how many people actually healed following the regimen prescribed by the doctor?
How to get out of adrenal insufficiency?
The data show us the cause of adrenal dysfunction – it is the inflammation. The endotoxins can cause massive systemic inflammation which directly affects the adrenal glands as well.
Resolve emotional stress, toxins and correct the deficiencies. Then healing occurs itself.
No need to take countless supplements to manage the adrenal “fatigue”. Adrenal fatigue does NOT EXIST and I wrote about that before.
It is not the fatigue. It is the dysregulation of hormonal and nervous system. Low cortisol levels have the underlying cause: it is the adrenal hyporesponsiveness to ACTH what is a major problem!
Adrenal glands produce and are controlled by hormones as well as neurotransmitters. Whether it is the most blamed cortisol or mostly underrated adrenaline – both are very strong hormones which have a huge impact on our health. Adrenaline plays a critical role as a neurotransmitter as well; which makes it even more important than cortisol in my opinion. But not a lot of doctors are concerned about that.
Emotional stress is the worst and hardest to eliminate
Turn off the TV for good
These days the TV is a shit. The only purpose of TV is to get you in front of it and play you the commercials. Most of those “great shows” they are trying to sell us on a daily basis have the additional purpose of brainwashing the people in every aspect of their lives.
Let go of things you can not change
Like really, if you are trying to change or resolve something which you know you can not do… Just let it go.
Maybe you already know the quote by Reinhold Niebuhr from his Serenity Prayer:
“God, give me grace to accept with serenity
the things that cannot be changed,
Courage to change the things
which should be changed,
and the Wisdom to distinguish
the one from the other.”
Meet only people you like
Whether it is your work or free time. You should be in company consisted only of people you like or tolerate. If anybody tells you something else he lies. Being around the people you don’t like won’t do any good and just make you stressed. Whether you are conscious about that or not.
Detoxification and supplementation…
I write about the supplements in many of my posts so I will just summarize the ideas here.
Then there are bile acids or artichoke tea to help with the bile flow which helps the endotoxin breakdown in the small intestine. Bile flow will significantly decrease the amount of endotoxins absorbed into the blood from the small intestine.
The best diet is hypoglycemic diet with low amount of starches which would otherwise feed bacteria and fungi in the gut.
The natural way how to increase cortisol levels is licorice root.
Inflammation = adrenal insufficiency
Sure, low adrenal function substantially contributes to inflammation as well but what do you think is first?
- Adrenal dysfunction just like that because adrenals got fatigued or because of bad luck?
- Deficiencies and endotoxemia because of bad diet, drugs and emotional stress?
That’s why adrenal insufficiency very rarely resolve on its own. The inflammation in the gut initially affects the adrenals and may lead to serious HPA axis dysregulation. Then dysregulated HPA axis affects the proper parasympathetic nervous system function (rest and digest is impaired). This leads to bad digestion which means SIBO/endotoxins, fungal overgrowth and deficiencies.
1.) Kanczkowski W, Chatzigeorgiou A, Samus M, Tran N, Zacharowski K, Chavakis T, Bornstein SR. Characterization of the LPS-induced inflammation of the adrenal gland in mice. Mol Cell Endocrinol. 2013 May 22;371(1-2):228-35.
2.) Beishuizen A, Thijs LG. Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis. J Endotoxin Res. 2003;9(1):3-24.