Adrenal Fatigue Is Bacterial Infection
This post will be just a short overview why you should stop hunting the useless supplements and protocols for adrenal “fatigue”:
Don’t get me wrong some of those supplements are very helpful when used right but rarely completely resolve the underlying problem. They may work for some time and after that people usually just up the dosages in hope they need to take “more of this and more of that” to get better.
You should understand that adrenal “fatigue” is caused by toxicity and deficiency just like every other chronic disease! In other words: adrenal fatigue is caused by bacterial infection.
Adrenal “fatigue” caused by endotoxin induced inflammation
The scientific paper “Characterization of the LPS-induced inflammation of the adrenal gland in mice.” describes the aspects of endotoxemia and associated adrenal gland insufficiency.
The authors concluded that adrenal dysfunction which is so often present in critically ill patients including the patients with sepsis may be the result of LPS induced inflammation.
In mice the systemic administration of endotoxin induced systemic inflammatory response syndrome (SIRS). Administration of endotoxin (LPS) led to increased levels of many proinflammatory cytokines, chemokines and other molecules. This caused massive infiltration of immune cells into the adrenal gland.
This endotoxin mediated inflammation was associated with increased cell death of adrenocortical and chromaffin cells.
Endotoxins disrupt the proper HPA axis function
It is well known that endotoxins are a powerful systemic stressor which activates the HPA axis. The major HPA axis response induced by endotoxin challenge is mediated via these cytokines: IL-1, IL-6 and TNF-alpha. These cytokines are the same which are heavily involved in inflammation associated with psoriasis. These cytokines stimulate the immune cells which in turn stimulate the various HPA axis pathways.
So even if you ever believed in adrenal “fatigue” as real organ fatigue this endotoxin induced HPA axis activation would perfectly fit in your belief model.
Scientific data from rat study proved that previous exposure to endotoxins results in hyporesponsiveness of adrenal glands to ACTH stimulation. ACTH is a major hormone responsible for activation of cortisol release.
Pretreatment with lipopolysaccharides (LPS – endotoxin) caused a significant decrease in corticosterone production which is a major glucocorticoid in rats.
Now just look at the next picture. You can see that ACTH levels in psoriatics are significantly higher and cortisol significantly lower than in healthy people. The results are the same in people with psoriasis as they are in the rats exposed to endotoxins.
Endotoxins are considered as the cause of psoriasis also by L. Bertók who published many papers about the importance of bile acids for breaking down the endotoxins in the small intestine.
All this data give us a clue that all those saliva cortisol tests and cortisol replacement therapies used for adrenal “fatigue” are mostly useless.
If endotoxemia which means bacterial infection causes low cortisol and overall adrenal insufficiency then why would anybody take replacement therapies instead of eliminating the infection?
Short-term replacement therapy may be OK and speed up the healing but how many people actually healed following the regimen prescribed by the doctor?
How to get out of adrenal insufficiency?
The data show us the cause of adrenal dysfunction – it is the inflammation. The endotoxins can cause massive systemic inflammation which directly affects the adrenal glands as well.
Resolve emotional stress, toxins and correct the deficiencies. Then healing occurs itself.