My Psoriasis Cause Theories
Endothelin may be one of the causes of redness and scaling in psoriasis since it may cause local hypoxia in the skin.
The most powerful known vasoconstrictor which is produced by the body is endothelin.  There are the studies which prove that the blood from psoriasis plaques contains the significantly higher levels of endothelin than the blood from psoriatics’ normal skin and skin from healthy people.[18, 19]
However it may be also that the first the psoriasis plaque is hypoxic (thick blood – platelets, rouleaux, fibrin, etc.) and the body in response to hypoxia release the endothelin.
|Psoriasis (guttate) on arm – the skin around the circles looks pale – like there was low blood flow. These circles are called – Woronoff rings.|
That’s why I am not convicted that psoriasis is the autoimmune disorder. I think that the skin cells which are destroyed by our immune system are already damaged by the bacteria/toxins and low oxygen content (the cells are dying from oxygen and nutrient starvation due poor blood flow) and that’s why our bodies make the new skin cells.
Redness is just a symptom of inflammation because the pathogens and toxins are there and body tries to clean up that tissues.
Endothelin is also found in the tumors so it fits with the theory that the cancers are also often caused by virus. Endothelin is involved also in other autoimmune considered diseases, but the question is if it is the cause (endothelin release caused by virus/bacteria) or the defense mechanism of the body.
I have two theories about the cause of psoriasis:
There are known viruses that cause the cells in the body to release endothelin – a powerful vasoconstrictor. In my first theory the virus/mycoplasma/CWD bacteria cause the vessels in the skin to constrict (maybe in order to create the low oxygen environment – oxygen deprived skin; or to avoid the immune cells). As the infection in the skin spreads the plaque gets bigger and bigger.
|Small plaque – infection in the microvessel(s)|
|Infection spreads – plaque grows|
|The infection/blocked vessel in deeper part of the skin|
You should imagine the smallest vessels in these picture as very tiny tubes which are just about 5-10 micrometers wide (red blood cells are about 8 micrometers wide) so just one red blood cell can flow through it at a time. And even the one RBC have to change the shape to get through the smallest micro-vessels (capillaries).
The cause why the plaques are red is probably not just because of the infection there (which causes the immune reaction) but also because of the inflammation/oxidative stress from low blood supply which should deliver enough oxygen, nutrients and remove the metabolic wastes from the cell metabolism.
The reason why there is a lot of dry skin is probably just because the body have to constantly produce new cells since the old ones are not even fully/right developed due to lack of oxygen and nutrients and are also damaged by metabolic wastes (oxidative stress).
2nd theory – I believe in this theory more
In the upper part of the skin is the pathogen which body tries to destroy. Since it is the intracellular pathogen (in the psoriasis plaque there are the recruited neutrophils and the neutrophils are often a sign of intracellular infection)  body makes the skin cells to proliferate fast so the pathogens in them will die along with the dead cells in which they hide. It is very possible that the infection is the intracellular Streptococcus pyogenes since the onset of guttate psoriasis is often 2-3 weeks after the Streptococcal pharyngitis (strep throat) caused by Streptococcus pyogenes.[196, 197, 198]
In order to slow the pathogen from spreading the body constrict the blood vessels in a way that the blood can easily flow just in a way from the body into the skin and not in a reverse way so the pathogens wouldn’t spread easily by flowing through the blood to another location in the body. Otherwise we would have psoriasis everywhere and had covered 100% of the skin on the body with psoriasis.
|The body intentionally regulates/inhibits the blood flow in the plaque in order to stop or slow the infection from spreading|
The cause why body can’t fight off the infection in the skin is because of the thick blood and overloaded body with the toxins which disrupt the communication between the cells (liver cells, skin cells, immune cells, etc.).
The rouleaux formations, fibrin, stiff RBCs, iron/hemoglobin deficient RBCs, damaged RBCs, poor liver function, etc. and plugged vessels with the various crystals and platelets don’t allow the immune system to clean up the psoriasis lesions fast enough until the pathogens infect the newly produced skin cells.
It is known that the intracellular pathogens can inhibit the cell apoptosis (programmed cell death) so they can live in those cells and proliferate.
That fact may be the cause why there is faster psoriasis skin proliferation during the healing (supplementing the bile acids). Actually the psoriasis plaque is less red and scaly for a few days and then for another 1-2 days it is more scaly than it would be without any treatment (without bile acids, omega 3, vitamin D3, etc.). This cycle repeats a few times in about 2-3 weeks until the plaque is all cleared and the normal skin appears.
Higher skin cell proliferation is not just in psoriasis. The researchers suggested that in the cutaneous (skin) Candida infections the body use the rapid skin proliferation as the defense mechanism to fight off the infection faster. 
If one of those two theories was true – then you would see the stupidity with all those immunity suppressing drugs. The proof that drugs are a bad idea is that after the immunosuppressants or steroids are not taken anymore, the symptoms come back and often even worse since the infection spread more over the body while the immune system was paralyzed by the drugs.
I think that psoriasis is the mix of the following:
– skin cells damaged by the pathogens and skin tissue hypoxia consequences
– damaged and undeveloped skin cells are destroyed/replaced by immune system
– the spots where psoriasis plaques develop are deprived of oxygen, nutrients and so there is a continual reperfusion injury  (That means something like bedsores or if you would tie the string around the finger (DO NOT TRY TO DO THIS it will cause permanent damage and even amputation may be needed!!!) and after about 20 minutes you would let the blood flow go there again in a full force.
That would cause massive inflammation since there would be a lot of damaged cells by oxygen and nutrients deprivation, possible proliferated bacteria, necrotic cells, oxidative stress – so the immune system would go haywire. The finger would be swollen, red, painful (some people can feel sometimes little pain when press the psoriasis plaque) since your body would be trying to clean up the mess.
So something similar goes on in the psoriasis plaques which are constantly deprived of oxygen because of endothelin mediated vasoconstriction and thick blood (fibrin, rouleaux, bacteria, toxins, higher glucose levels, anemia due to infection or low iron, etc.).
That’s why the new blood vessels are growing in the psoriasis plaques – angiogenesis. The angiogenesis process fits to both of my theories since it is present because the body is trying to improve the supply of the tissues with the oxygen, nutrients and white blood cells to resolve the problem – infection.
It is even possible that no pathogen in the skin is needed for psoriasis plaques creation
The thick blood is a very important factor in this theory since when the red blood cells are clumped together and there is a lot of fibrin in the blood, it is almost impossible for the red blood cells to delivery the oxygen into the upper parts of the skin. And without the oxygen the skin cells start to produce endothelin (vasoconstrictor) which can put the body into the vicious cycle when endothelin itself even more blocks the oxygenation of the tissues since the RBCs can not flow easily through the constricted vessels.
And that vicious cycle can be broken down just by the less fibrin in the blood, not clumped red blood cells, etc. Liver is the main organ which is responsible for clean, thin and healthy blood.
So theoretically it is possible that there is no pathogen in the skin what is responsible for psoriasis plaques, but I don’t think that. I think that the pathogens are the cause.