Epigenetics or Always Blame Genes?
One big problem even with many natural therapists and people using the natural methods to improve their psoriasis or well being is that they are always trying to suppress something (genetic expression?). They want to label the symptoms they have, they want to name the disease they have and then they want to use man-made drugs or natural supplements to alleviate the symptoms.
“If your tongue has white coating, do not blame your genes.”
One thing they are not aware of is that they actually can’t cure the disease which has a name.
Because all those chronic diseases names often containing words like “idiopathic” and “syndrome” in their are incurable in modern allopathic medicine.
Allopathic medicine gives names to symptoms and then according to the protocol it provides some drugs that suppress those symptoms. Then they call the state of the body as “remission” because they know that it is just a matter of time when the drugs stop working or patient will require higher dose “to stay in remission”.
The real naturopathic doctors will not name the diseases they will create the health. It is not about labeling bunch of symptoms and put the patient on supplements. What difference would be there between allopathic doctor and naturopath if they both were just masking the symptoms – one by drugs and the other with supplements.
The point is to get to the root cause of those symptoms not label them and take something to get some relief. And believe it or not the most common cause is infection – SIBO, fungus in the digestive tract, root canals or some other dental infection.
Pyroluria – it is not a genetic problem
Pyroluria is also known as Kryptopyrrole, Mauve Factor or Hemepyrrole. The most people blame the genes for the bunch of symptoms that are known under those labels.
Pyroluria is the name of the condition in the body when excess pyrroles (chemical compounds) are created during the hemoglobin synthesis. Those pyrroles then bind to vitamin B6, zinc, omega 6 fatty acid – GLA (Gamma-linolenic acid) and make them unavailable for the body what results eventually in various symptoms and progressive deterioration of the whole body.
In one discussion on Facebook I was trying to say the group members that the condition in the body when pyrroles accumulate or are created in huge amounts is probably not the problem of not taking high doses of zinc and vitamin B6 that would be needed due to genetic mutation. Well, it may be in some people with the strong genetic predisposition but mostly it is the problem of some chronic infection (SIBO – bacterial and/or possible fungal infection) and the presence of pathogenic toxins that may cause the body to produce pyrroles during the hemoglobin synthesis.
Most people on Facebook was saying it is purely genetic. I say yes – the genes involved in hemoglobin synthesis are affected by toxins from pathogens (SIBO, fungal toxins – mycotoxins) – genes just respond the way they respond to toxin. Is it possible that some people were unable to understand what I was trying to say, or maybe they did not want to understand?
Accumulation of pyrroles in the blood may be caused by increased production or slower excretion from the blood since it is accepted that some pyrroles are common in the blood of all people.
My point is to show that most diseases, syndromes and health problems are related to the digestion and gut. Stomach should be sterile, small intestine with just very small amount of bacteria and in large intestine there should be the balanced flora with friendly bacteria. If this is not present in some person which has developed some health problem then all that labeling of the diseases and blaming genes is silly.
Bacteria and fungus are killing you from within, you are rotting but the problem is bad genes? Sure, billions years of evolution and only the best survived but suddenly we have half of the world population with bad genes. How can anybody believe this? I wonder why wild living animals are healthy.
If wild living animals have some bad genes they will die very soon and not live the average life span of their species with some chronic degenerative illness. The opposite we can find in the pets many of us have at home. They will develop arthritis, anemia, cancer, anxiety, obesity, tooth decay, etc… Is that all because of the bad genes or there is something else like nutrition that cause them to go down the hill with their health?
Some people there in the discussion on the Facebook were even thinking that I am trolling and did not answer to my question if they though that problem in Pyroluria is pyrroles in the blood.
I am not saying that there are no genetic variations/mutations causing the problems but today hundreds of millions of people are really ill and the best explanation is – it is GENETIC. No, most cases of the diseases are not genetic.
TNF-alpha release in inflammatory and “autoimmune” diseases is a genetic problem?
Let me make one correlation with sepsis. When endotoxins reach the blood various cells (macrophages, endothelial cells, adipose tissue cells, …) release the TNF-alpha which is the major mediator of inflammation and immune response.
That’s why immunosuppressive drugs (like ciclosporin or biologic drugs) work for psoriasis and their effectiveness is dose dependent. When those drugs are taken regularly they work and clear up the skin. The problem gets back shortly (days) after the dose is lowered or completely discontinued – psoriasis comes back and often even worse than it was before.
Ever wondered why?
Now if you believe in endotoxin theory of psoriasis cause which is actually scientifically very accurate and is backed by strong data then it is common sense that body will try to make more TNF-alpha when something (immunosuppressive drugs) are blocking the TNF-alpha production or its job in the body. The body knows that there should be TNF circulating so it will produce more of it.
Then according to that thinking of many people that always blame genes – they should say that TNF-alpha release and disease (symptoms) that results from it is also genetic and irreversible. And yes it is genetic since ALL processes in the body are affected by our genes – but the problem is not TNF-alpha production. The problem is the endotoxins leaking to the blood usually from the small intestine or dental infections.
Despite the fact that TNF-alpha release is needed to survive it can be modulated by natural compounds as well as the proteins/hormones the body produce (like peptide hormone hepcidin).
Health of the body is just about the balance.
Mystery of psoriasis as autoimmune disease
I still do not understand how and why psoriasis is considered as autoimmune disease? Does anybody in the past decided that psoriasis is autoimmune and most researchers and doctors consider psoriasis as autoimmune disease from that time despite the fact that there in not ONE proof that would prove that. Just because the body’s immune cells are at the sites of psoriasis plaques that does not prove autoimmunity.
Actually for every clever mind it raises the questions why those immune cells are there and if it could be possible that those immune cells are trying to protect the body from some infection.
1.) Ivana De Domenico, Tian Y. Zhang, Curry L. Koening, Ryan W. Branch, Nyall London, Eric Lo, Raymond A. Daynes, James P. Kushner, Dean Li, Diane M. Ward and Jerry Kaplan. Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest. 2010;120(7):2395–2405.