Adrenaline: The Effects of Alpha and Beta Adrenergic Receptors on Vasoconstriction and Blood Flow in Psoriasis

Adrenaline plays a big role in psoriasis – whether it is the adrenaline released due to emotional stress or adrenaline released due to hypoglycemic episodes. The levels of adrenaline are statistically higher in psoriatics than healthy people or people with some other skin diseases.

Image source: F. Z. Zangeneh and A. Fazeli. THE SIGNIFICANCE OF STRESS HORMONES IN PSORIASIS. Acta Medica Iranica 2008; 46(6): 485-488.

Image source: F. Z. Zangeneh and A. Fazeli. THE SIGNIFICANCE OF STRESS HORMONES IN PSORIASIS. Acta Medica Iranica 2008; 46(6): 485-488.

There are two types of adrenaline receptors – Alpha and Beta receptors.

The two specific types I want to talk about in this article are – Alpha adrenergic receptor (mostly Alpha-1) and Beta-2 adrenergic receptor.

Alpha adrenergic receptors

One of the jobs of Alpha adrenergic receptors upon activation by adrenaline is to constrict the smooth muscle which is lining the blood vessels. That’s why you may develop along the psoriasis also cold hands and feet, incontinence, muscle pain and many other symptoms – all these may be caused directly on indirectly by constriction of blood vessels and smooth muscles in the places like urinary bladder. The result is often an impaired blood flow in the specific area.

Beta-2 adrenergic receptor

The job of Beta-2 adrenergic receptor is quite an opposite. Its job upon the activation by adrenaline is to relax the smooth muscle.

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.