Milk Thistle Can Cure Psoriasis But It Is Very Estrogenic And May Cause Gynecomastia
There is a lot of liver supplements useful in psoriasis and one of the most promoted and recommended is Silymarin extracted from Milk Thistle seeds. The positive effects of the active ingredient(s) silymarin are well known and scientifically proved as being a potent antioxidant and effective especially in liver problems. Psoriasis is one of the health issues that can be markedly improved by silymarin but is it really worth to take Milk Thistle extract to help your liver?
Most people are well aware of the effects of some of the soy isoflavones (Genistein and Daidzein) which act as the estrogens in the body. There is a big hype regarding the soy being the biggest estrogenic evil and many people avoid soy even in trace amounts which is silly in my opinion. When saying in trace amounts I am not talking about eating the soy foods like tofu, tempeh, natto and miso.
I am talking about the soy lecithin which is actually a highly concentrated extract of some beneficial nutrients found in soy. Taking the soy lecithin is nothing like eating the whole food soy or common processed soy products.
However, we still have an option in taking the sunflower lecithin instead.
On the other hand the same people who avoid soy as hell take the silymarin supplements which are the highly concentrated extracts of estrogenic compounds found in Milk Thistle.
Don’t you believe?
Estrogenic Milk Thistle extract for Psoriasis?
Here is a testimony of guy who took 1 tablet of Milk Thistle extract for several months and developed gynecomastia.
I took Milk Thistle extract (175 mg of the 80% standardized extract) daily for several months to help with liver function and developed gynecomastia (no, I never used steroids). Many other men have experienced this side effect as well, just google ‘Milk Thistle gynecomastia’.
If you are a male, I strongly suggest you consider other sources of anti-oxidants or different supplements for liver support.
Source Link: https://www.erowid.org/experiences/exp.php?ID=98457
Use of Milk Thistle for liver support is very popular in bodybuilding community, especially in those who use the anabolic steroids which are very hard on the liver.
The bodybuilders may not be affected by Milk Thistle supplements as much due to the fact that they take the aromatase inhibitors which if taken in high doses may almost completely shutdown the natural (and beneficial) production of estrogens. The Anastrozole (an aromatase inhibitor) is capable to inhibit the aromatase enzymes about 97% when taken 1mg daily. 
Some drugs like Tamoxifen (which is also a popular drug in bodybuilding) act directly on estrogen receptors thus may block the estrogenic effects of silymarin (which is an Estrogen receptor Beta agonist). [10,11]
The aromatase inhibitors work via inhibition of conversion of hormones like testosterone to estrogens and have no effect on exogenous (administered substance – not produced in the body) estrogenic substances like those found in Milk Thistle!
Some bodybuilders abusing the anabolic steroids have their breast glands removed in order to avoid the gynecomastia.
Average levels of Estradiol in men and women
Estradiol just like the testosterone in the other hand are naturally produced in both men and women.
Estradiol is the most potent form of estrogen produced in the body.
The ratio and total levels of these hormones is what really matters in order to make women look, behave and function as women and to make man look, behave and function as men.
The normal range of estradiol levels found in fertile men was 10–82 pg/ml.