Sinusitis, Pituitary Tumor and Psoriasis Caused By Fungal Infection

Whether you have psoriasis, sinusitis, pituitary tumor or unfortunately all of those this blog post may come very handy to you.

This will be about the ignorance, low professional intelligence and poor researching and professional qualities of many doctors out there.

Psoriasis is a chronic inflammatory disease which is impossible to cure according to very most doctors in the world. Yes, we all know that and this blog is about all but the different view on this complex disease.

But why in the world are doctors so lazy or how I should call them when it comes to somehow more serious diseases like pituitary tumors?

Yes, I know – tumors or cancer – are caused by many different causes and it is (almost) impossible to pinpoint the exact cause in every particular case of cancer in each patient (at least according to mainstream medicine).

The point of this blog post is to show you how many people suffer due to poor skills of doctors who do only what they were taught in a school (and often even less than that)!

There is a lot of people who seriously doubt any possible connection between the psoriasis and fungal or yeast infections. However, as you will read this blog post you will find out that even less explicit diseases like pituitary tumors can be actually caused by fungi or even the tumors may be the fungal masses themselves!

Chronic Sinusitis is caused by Fungal infection

 

Image Source: https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0024566/
Created for the National Cancer Institute, http://www.cancer.gov

 

The study “The Diagnosis and Incidence of Allergic Fungal Sinusitis” by Mayo Clinic from 1999 concluded that 96% of cases of chronic sinus infections had positive fungal cultures.[1]

Did you hear that ever in your life from your doctor?

96% of patients with chronic sinusitis have fungal infections in their sinuses!

Now, you may say that there is only a handful of people with pituitary tumors…

The truth is that benign (not deadly) pituitary tumors are fairly common!


The current metaanalysis estimated the prevalence rate of pituitary adenomas to be 16.7%. Separate analyses of postmortem and radiologic data produced estimated prevalence rates of 14.4% and 22.5%, respectively. These figures indicate that pituitary tumors are fairly common in the general population. With macroadenomas occurring at a rate of 1 in 600 persons, there also are likely many persons with unrecognized macroadenomas.
” [3]

Even though the most pituitary tumors are not deadly the problem is that they can affect the vision as they may make a pressure on the optic nerves.

Let’s check where are the sphenoid sinuses (these sinuses are the nearest from all sinuses to pituitary gland) located and what tissues neighboring them.

 

Image Source: http://pituitary.ucla.edu/pituitary-adenomas

 

Let’s see, pituitary gland is a hell of a near to sphenoid sinuses.

Would it be possible that fungal infection of the sphenoid sinuses and the subsequent immune reaction could mess up the pituitary gland in any way?

Maybe inflammatory processes induce the tumor growth and maybe the tumor is actually a fungal mass…

And this is not just a theory of my own.

We have a lot of studies and case reports linking the fungal infections, inflammation of the sinuses and pituitary gland tumors (adenomas).

 

“Pituitary macroadenoma with hemorrhage. Axial T1W (a) and T2W (b) images reveal a pituitary mass (arrow) showing intratumoral hemorrhage. On postcontrast coronal (c) and sagittal (d) images, the lesion demonstrates mild enhancement with left cavernous sinus invasion. Proton MR spectroscopy shows prominence of lipid-lactate peak with reduction of all other metabolites”
Image and Text Source: Indian J Endocrinol Metab. 2011 Sep; 15(Suppl3): S216–S223. Imaging of the pituitary: Recent advances; Vikas Chaudhary and Shahina Bano
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183511/

 

If you can not clearly see where is a pituitary gland and tumor check the next image…

 

Image Source: http://pituitary.ucla.edu/pituitary-adenomas

 

Pituitary Aspergillosis Mimicking Pituitary Tumor

Here is one case report from 2000 describing the 37-year old woman who developed a condition mimicking pituitary tumor but the real problem was a fungal infection – Aspergillosis!

The authors of this case report mentioned how rare it is as they have found only 6 cases in the scientific literature back then. But is it really so rare?

Maybe it is just so very underrated…?!?!

 

Image Source: Jae-Hee Lee, Young Sup Park, Kyoung Mee Kim, Ki Jun Kim, Chang Ho Ahn, Sung Yong Lee, Kyu H. Choi. Pituitary Aspergillosis Mimicking Pituitary Tumor. AJR:175, December 2000, p. 1570-1572

 


Although aspergillosis of the paranasal sinuses is a well-recognized form of fungal infection, involvement of the pituitary gland by aspergillosis is extremely rare and can be misdiagnosed as a pituitary tumor.

We describe a case of invasive aspergillosis that manifested as a pituitary mass and osteomyelitis of the clivus and upper cervical spine in a young immunocompetent patient without evidence of sphenoidal sinusitis.
” [2]

Even though the authors of that case report considered pituitary gland to be affected by aspergillosis as a fairly rare phenomenon, I think the opposite.


A 37-year-old woman who had no history of severe illness or trauma was admitted to the hospital because of amenorrhea and blurred vision for the last year. She took medication for amenorrhea.
” [2]

Ammenorhea is the absence of menstrual period in woman of reproductive age.


Most of the findings from the basal hormonal studies were within the normal limits except for a slight elevation of the serum prolactin level.

As you can see, the laboratory findings did not show anything major. The slight elevation of prolactin was the only clue.

Image Source: Jae-Hee Lee, Young Sup Park, Kyoung Mee Kim, Ki Jun Kim, Chang Ho Ahn, Sung Yong Lee, Kyu H. Choi. Pituitary Aspergillosis Mimicking Pituitary Tumor. AJR:175, December 2000, p. 1570-1572


Histologic examination of the excised pituitary gland showed marked acute and chronic inflammatory cell infiltration with focal wellformed granulomas. The central portion of granulomas contained necrotic cellular debris with some neutrophils. After periodic acid– Schiff and methenamine silver staining, bundles of hyphae were found in the necrotic areas, consistent with aspergillosis

Amphotericin-B therapy was initiated on the fifth postoperative day.
“[2]

Experts need to use a special stains in order to see the possible fungal infiltration of the tissues under the microscope.

Intravenous administration of Amphotericin-B is a standard therapy for severe cases of fungal infections.


Although our patient had no evidence of sinusitis, it is presumed that Aspergillus spores previously inhaled in the sphenoidal sinus might transverse the bone along the vascular channels causing osteomyelitis of the skull base and pituitary aspergillosis.
“[2]

The authors suspected that inhalation of the Aspergillus spores was the cause of pituitary aspergillosis.

As you can see, it is not necessary to have a fungal sinusitis to develop a pituitary infection.

Conclusion

Are there hundreds of thousand or even millions of people walking diagnosed with idiopathic pituitary tumor (word “idiopathic” means “no known cause”) even though the real cause of their tumor is fungal infection?

Just ask people with pituitary tumors if they have or had chronic sinusitis in the past. I think a lot of them will confirm that they have struggled with sinuses for quite a bit of time.

 

Hopefully, this blog post gave you a little insight into what it takes for the doctors to do a proper diagnosis and why it is important to find the root cause of that diagnosis.

Labeling very most diseases as “no known cause” and just prescribe a drug for them is not the best way how to fulfill the Hippocratic Oath.

“I will utterly reject harm and mischief.”

References:

1) JENSU. PONIKAU, MD; DAVID A. SHERRIS, MD; EUGENE B. KERN, MD; HENRY A. HOMBURGER, MD;EVANGELOS FRIGAS, MD; THOMAS A. GAFFEY, MD; AND GLENN D. ROBERTS, PHD. The Diagnosis and Incidence of Allergic Fungal Sinusitis. Mayo Clinic 1999.

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.577.8208&rep=rep1&type=pdf

2) Jae-Hee Lee, Young Sup Park, Kyoung Mee Kim, Ki Jun Kim, Chang Ho Ahn, Sung Yong Lee, Kyu H. Choi. Pituitary Aspergillosis Mimicking Pituitary Tumor. AJR:175, December 2000, p. 1570-1572
https://www.ajronline.org/doi/pdf/10.2214/ajr.175.6.1751570

3) Shereen Ezzat,M.D.,Sylvia L. Asa,M.D., Ph.D.,William T. Couldwell,M.D.,Charles E. Barr,M.D., M.P.H.,William E. Dodge,M.S., M.B.A.,Mary Lee Vance,M.D., Ian E. McCutcheon,M.D. The Prevalence of Pituitary Adenomas – A Systematic Review. CANCER August 1, 2004 / Volume 101 / Number 3

https://pituitary.org/images/Prevalence_Of_Pituitary_Adenomas.pdf

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