How AIDS Leads To Psoriasis
Psoriasis is reported to be more prevalent in HIV infected population compared to HIV negative population.
What is a paradox the scientists are trying to resolve?
How is it that immunocompromised patients develop the disease which is considered to be caused by overactive immune system…?
There are only two possible reasonable explanations which come to my mind:
- Psoriasis is not a disease of immune system in the first place
- HIV infection does not cause the breakdown of all immune system mechanisms
Does HIV virus exist and does it cause AIDS?
Some of you may even question the real cause of AIDS or existence of the HIV virus but in this post I won’t go into that.
Sure, there is a lot of reasonable discussion about the origin of HIV virus which is known and generally accepted as the cause of AIDS (Acquired Immune Deficiency Syndrome).
If you are interested in this topic I would recommend you to read the book “Inventing the AIDS Virus” by Peter H. Duesberg and watch the talk by Dr. Robert Willner, MD who presented the unconventional views on AIDS and HIV on conference in Los Angeles in 1994.
AIDS cause summary?
AIDS can be caused by many different causes – nutritional deficiency, toxicity (prescription and recreational drugs), stress, various infections…
AIDS does not mean HIV infection just like HIV infection does not mean AIDS.
There are people with positive HIV test results who are healthy without any symptoms of AIDS and people who have negative HIV test results who still suffer from the symptoms of AIDS (weak immune system).
But for the purposes of this blog post just consider the next three terms interchangeably: “AIDS”, “HIV infection” and “weak immune system”.
In the end it does not matter if AIDS syndrome is caused by HIV virus, some other virus, fungal infection, drug or heavy metal poisoning.
AIDS leads to opportunistic infections, infections trigger psoriasis
The hallmark of AIDS is the weak immune system which creates a perfect environment for the opportunistic infections which would have otherwise no chance to invade the healthy body.
Fungal infections are the most common cause of death in HIV-infected patients.
Actually, targeting the fungal infections in AIDS patients would bring a significant decrease in AIDS-related mortality as 47% (that is 700 000 people annually) of all AIDS-related deaths is caused by fungal infections. 
Fungi are major contributors to the opportunistic infections that affect patients with HIV/AIDS. Systemic infections are mainly with Pneumocystis jirovecii (pneumocystosis), Cryptococcus neoformans (cryptococcosis), Histoplasma capsulatum (histoplasmosis), and Talaromyces (Penicillium) marneffei (talaromycosis). The incidence of systemic fungal infections has decreased in people with HIV in high-income countries because of the widespread availability of antiretroviral drugs and early testing for HIV. However, in many areas with high HIV prevalence, patients present to care with advanced HIV infection and with a low CD4 cell count or re-present with persistent low CD4 cell counts because of poor adherence, resistance to antiretroviral drugs, or both.
The AIDS scientists in 1987 knew that bacterial, viral and fungal infections can trigger psoriasis. 
So, why even in 2018 it is so hard for the doctors and psoriasis scientists to understand that psoriasis is usually caused by infection (which leads to neuronal inflammation = psoriasis)?
Psoriasis and fungal infection in HIV infected patient
One report from 1993 describes a case of psoriasis, seborrheic dermatitis and disseminated cutaneous histoplasmosis in a patient infected with HIV. 
There is another case report of patient living with HIV infection for 20 years who developed histoplasmosis. 
The wart-like lesions were predominantly on face and upper body. Some of the other comorbidities were renal dysfunction, low counts of red and white blood cells as well as low platelet counts.
The mycological examination revealed the presence of histoplasma in lesions as well as in the blood. Serology showed no increase in specific antibodies which would revealed the presence of fungus, though.
The part of the treatment was reintroduction of antiretroviral drugs and Itraconazole 3 x 200 mg daily for the first 3 days and then 400 mg/day.
11 months later the lesions were healed, patient gained 20 kilograms (44 lbs) and generally improved.